Fig. 9

Effects of heat-killed P. intermedia on the transcriptomics of tumor suppressors in transplanted tumor model mice. a Chord diagrams of downregulated genes and pathways. Red asterisks indicate classic tumor suppressor genes. b Volcano plot demonstrating the differentially expressed genes in the heat-killed P. intermedia group compared with the control group. The genes with significantly increased or decreased levels are colored in red or blue, respectively (Wald test, p value < 0.05, and fold change > 2). c Representative images of FASL and P63 IHC staining. The data are shown as the mean ± SD and were analyzed by t test. *P < 0.05, ****P < 0.0001