Fig. 5

Heat-killed P. intermedia accelerated transplanted tumor growth in mice. a Flow chart of transplanted tumor experiments. b Tumor volume changes in mice. c Body weight changes in mice. d Gross morphology of dissected tumors in each group. e Differences in tumor weight between the heat-killed P. intermedia and control groups. f Differences in tumor volume between the heat-killed P. intermedia and control groups. g Invasive fronts (black arrows), muscle (M) and perineural (closed arrowheads) invasion of OSCC tissues (T) are shown according to H&E staining, KI-67 and MMP-9 expressions were determined by IHC staining. h Invasive mode comparison between the heat-killed P. intermedia and control groups. i, j The relative AOD of KI-67 and MMP-9 IHC staining was compared between the heat-killed P. intermedia and control groups. Data were analyzed by t test. ^#P < 0.05, ***P < 0.001, ****P < 0.0001