Fig. 12

a Correlation analysis between the gene expression of three tumor suppressors and tumor-associated factors. Pairwise comparisons of various factors are shown, with a color gradient denoting Spearman’s correlation coefficients. Red and blue nodes denote positive and negative correlations, respectively. Line width corresponds to Mantel’s r statistic for the corresponding distance correlations, and line color denotes statistical significance. b Schematic of P. intermedia-induced OSCC progression showing the effects of heat-killed P. intermedia on the TME and tumor suppressor genes