Table 3 Summary of prognostic models for sarcomas based on FRGs
From: Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects
Time | Target | Screening method | Hub genes for Prognostic model | Efficiency verification | Refs. |
|---|---|---|---|---|---|
2021 | Soft tissue sarcoma | Univariate Cox → LASSO → Multivariate Cox | MUC1, GSS, HELLS, RPL8, ALOX15B, NOX5, CD44, ISCU, NCOA4, RGS4, SETD1B, GCLM | ①GEO database ② ROC curve ③ K-M survival analysis | [234] |
2021 | Osteosarcoma | Univariate Cox  → LASSO → Multivariate Cox | G6PD, PEBP1, PGD, DPP4, SLC39A8, SOCS1, ATG7, MYC, ALOX15B, CBS, EGLN1, MUC1 | ①GEO database ② Time-dependent ROC | [9] |
2022 | Soft tissue sarcoma | Log-rank  → Wilcoxon rank sum → Univariate Cox → Multivariate Cox | EPAS1, STMN1, CXCL2, NQO1, HELLS, IL6 | ①GEO database ② Time-dependent ROC | [235] |
2022 | Uterine carcinosarcoma | Univariate Cox  → LASSO | PGD, HSF1, ISCU, PLIN2, GPT2 | ①GEO database ② ROC curve | [204] |
2022 | Sarcoma | Univariate Cox → LASSO | SLC7A11, FANCD2, CISD1, ATP3MC3 | ①ROC curve ② K-M survival analysis | [236] |
2022 | Osteosarcoma and Chemotherapy resistance | Log-rank → Univariate Cox → Multivariate Cox | CBS, COCS1, EGFR | ①GEO database ② Time-dependent ROC | [237] |
2022 | Osteosarcoma | Univariate Cox → LASSO → Multivariate Cox | PGD, G6PD, ACSF2, MT1G, FADS2, CBS | ①ROC curve ② K-M survival analysis | [238] |
2022 | Ewing Sarcoma | Univariate Cox → Random survival forest algorithm → Multivariate Cox | AURKA, RGS4, RIPK1 | ①GEO database ② ROC curve ③ K-M survival analysis | [239] |
2022 | Osteosarcoma | Univariate Cox → LASSO | TP53, HMOX1, SLC7A11, HRAS, VEGFA, TXNRD1, CBS, G6PD | ①GEO database ② ROC curve | [240] |
2022 | Osteosarcoma | Univariate Cox → LASSO → Multivariate Cox | LRRC1, ACO2, CTNNBIP1 (FRG subclusters) | ①ROC curve ② K-M survival analysis ③ Calibration curves | [241] |
2022 | Osteosarcoma | WGCNA  → LASSO → Multivariate Cox | COL5A2, HOXB4, UNC5B | ①GEO database ② ROC curve ③ K-M survival analysis | [242] |
2022 | Osteosarcoma | Univariate Cox → LASSO → Multivariate Cox | ACSL4, HMOX1, GPX4, PRNP, ATG7 | ①TARGET and GEO database ② K-M survival analysis | [243] |
2023 | Osteosarcoma | Univariate Cox → LASSO → Multivariate Cox | ACSL5, ATF4, CBS, CDO1, SCD, SLC3A2 | ①GEO database ② ROC curve ③ Subgroup analysis | [244] |
2023 | Osteosarcoma | Univariate Cox → LASSO | MUC1, MAP3K5, LURAP1L, HMOX1, BNIP3 | ①GEO database ② ROC curve ③ Univariate and multivariate Cox | [245] |