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Fig. 9 | Experimental Hematology & Oncology

Fig. 9

From: Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

Fig. 9

ADAR1 loss simultaneously strengthens the effects of sorafenib (Bay 43–9006) on intracellular ROS accumulation and regulation of Keap1/Nrf2 pathway in HCC cells. A–D DCFH-DA fluorescent probe for detecting intracellular ROS level of HepG2 and SMMC-7721 cells with Bay 43–9006 exposure and/or sh-ADAR1 transfection. Bar, 20 μm. E–J Immunoblot analysis of Keap1 or Nrf2 expression in HepG2 and SMMC-7721 cells with Bay 43–9006 exposure and/or sh-ADAR1 transfection. **p < 0.01; ***p < 0.001; ****p < 0.0001

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Experimental Hematology & Oncology

ISSN: 2162-3619

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