Fig. 8

ADAR1 loss strengthens the inhibiting effect of sorafenib (Bay 43–9006) on HCC cell proliferation and the promoting effect on apoptosis. A–D EdU staining for proliferation of HepG2 and SMMC-7721 cells with Bay 43–9006 administration and/or sh-ADAR1 transfection. Bar, 20 μm. E–H Flow cytometry analysis of apoptotic level of HepG2 and SMMC-7721 cells with Bay 43–9006 administration and/or sh-ADAR1 transfection. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001