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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

Fig. 5

ADAR1 deficiency enhances the inhibiting effect of oxidative stress agonist tBHP on HCC cell proliferation and the promoting effect on apoptosis. A–D EdU staining for proliferation of HepG2 and SMMC-7721 cells with tBHP administration and/or sh-ADAR1 transfection. Bar, 20 μm. E–H Flow cytometry analysis of apoptotic level of HepG2 and SMMC-7721 cells with tBHP administration and/or sh-ADAR1 transfection. **p < 0.01; ***p < 0.001; ****p < 0.0001

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