Fig. 3

ADAR1 is responsible for apoptosis, and oxidative stress in HCC cells. A–F Flow cytometry analysis of apoptotic level of HepG2 and SMMC-7721 cells with sh-ADAR1 or ADAR1 overexpression transfection. G–L DCFH-DA fluorescent probe for measuring intracellular ROS level of HepG2 and SMMC-7721 cells with sh-ADAR1 or ADAR1 overexpression transfection. Bar, 20 μm. M Volcano plots of differentially expressed genes between sh-NC and sh-ADAR1 HCC cells. N, O Biological processes and KEGG pathways enriched by the differentially expressed genes. *p < 0.05; **p < 0.01; ****p < 0.0001