Fig. 1

ADAR1 exhibits high expression in HCC and correlates to clinical outcome. A Pan-cancer analysis of ADAR1 expression in tumors and matched normal tissues from TCGA database via TIMER2.0 tool. B Distribution of ADAR1 expression across normal, tumor and metastatic tissues from TCGA database. C Paired comparison of ADAR1 expression in HCC tumors and matched normal tissues. D, E Immunohistochemistry of ADAR1 expression in tumors and matched normal tissues. F Comparison of ADAR1 expression detected by real-time quantitative PCR in hepatocytes (L-02) with HCC cells (Huh7, HepG2, Hep3B, and SMMC-7721). G, H Immunoblot analysis of ADAR1 expression in hepatocytes and HCC cells. I Survival curves of patients with high and low ADAR1 expression in HCC patients. J–L Real-time quantitative PCR and immunoblot analysis of ADAR1 expression in stage I/II and stage III/IV patients. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001