Table 7 Constituents of ADCs used in lung cancer treatment
From: Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
ADC drug name | Payload | Linker | Antibody |
|---|---|---|---|
T-DM1 | Emtansine | Thioether linker | Trastuzumab |
T-DXd | Deruxtecan | DXd linker | Trastuzumab |
ADCT-402 | Pyrrolobenzodiazepine | Di-thiomaleimides | Loncastuximab tesirine |
HER3-DXd | Deruxtecan | Tetrapeptide linker | Patritumab |
MRG003 | MMAE | Val–Cit | MMAE |
Teliso-V | MMAE | Mc-vc-PAB | ABT-700 |
DS-1062a | Topoisomerase I inhibitor | Tetrapeptide linker | Datopotamab |
IMMU-132 | Topoisomerase I inhibitor | CL2A linker | Sacituzumab |
ABBV-399 | MMAE | Valine glutamic acid linker | ABT-700 |
ABBV-181 | PBD dimer | Val-Ala linker | DLL3 antibody |
Rova-T | PBD | Mc-vc-PAB linker | SC16 |
BA3011 | MMAE | Val–Cit | Sggc-Fc |
TIVDAK | MMAE | Enzyme-sensitive linker | TF antibody |
PF-06647020 | Auristatin-0101 | Val–Cit | Cofetuzumab |
SAR-408701 | DM4 | SPDB | SAR408377 |
XMT-1536 | MMAF | Succinimidyl 4-(N-maleimidomethyl) Cyclohexane-1-carboxylate | NaPi2b antibody |
XMT-1592 | MMAF | Dolasynthen | NaPi2b antibody |
MRG003 | MMAE | Val–Cit | EGFR antibody |
MGC018 | Docamycin | Val–Cit | Omburtamab |
CX-2009 | DM4 | Enzyme-sensitive linker | Praluzatamab |
IMGN901 | Maytansine DM1 | Cleavable SPP linker | CD30 antibody |
XMT-1522 | MMAF | Fleximer polymer linker | HT-19 |
SG | SN-38 | Noncleavable linker | Sacituzumab |
Glembatumumab vedotin | MMAE | Mc-vc-PAB | Glembatumumab |
Anetumab ravtansine | DM4 | Cyclohexane-1-carboxylate | MF-T |
Tisotumab vedotin | MMAE | Enzyme-sensitive linker | TF-011 |
EnaV | MMAE | Mc-vc-PAB | AXL-107 |
BL-B01D1 | ED04 | Enzyme-sensitive linker | EGFR and HER3 antibody |
SYSA1801 | LND002 | pH-sensitive linker | CLDN18.2 antibody |
TORL-1–23 | MMAE | Val–Cit | CLDN6 antibody |
CBP-1008 | MMAE | MC-VC | FRα and TRPV6 antibody |
ABBV-221 | MMAE | Val–Cit | EGFR antibody |
PF-06263507 | MMAE | MC linker | TPBG antibody |
BMS-986148 | Duocarmycin | Val–Cit | MSLN antibody |