Table 4 Common PDC payloads
From: Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
Type of toxic payload | Payload | Representative tumor-targeting PDCs |
|---|---|---|
Chemical drug | Paclitaxel | Paclitaxel-poly(L-lysine) conjugate (PTX–PLL), ImmunoGen 853 |
| Â | Amanitin | Adcetris, Kadcyla, Mirvetuximab soravtansine |
| Â | Doxorubicin | TAT-doxorubicin, RGD-doxorubicin |
| Â | MTX | Glembatumumab vedotin, NPY-MTX conjugate |
| Â | Cathinone | ALOS4-camptothecin conjugate, SG3199 |
|  | Phenylbutyric acid nitrogen mustard | Benzenebutanoic acid nitrogen mustard–AAAk conjugate, EMD 525797 |
Nonchemical drug | TNF | NGR–hTNF, Etanercept, Infliximab |
|  | siRNA | cRGD–siEGFR, Atu027 |
| Â | AONs | Pip-AONs, AVI-4126 |