Table 3 Common ADC payloads
From: Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
Type of toxic payload | Payload | Representative tumor-targeting ADCs |
|---|---|---|
Microtubule-targeting payload | Maytansinoids | PF-06647020 |
| Â | Auristatin | IMGN901, MRG003, Teliso-V, BA3011 TIVDAK, Glembatumumab vedotin, Tisotumab vedotin, EnaV |
| Â | Eribulin | BB-1701 |
| Â | Tubulysins | EC1428 |
| Â | Cryptophycins | Dictyostatin |
|  | EG5 inhibitors | – |
DNA-targeting payload | Enediyne | Loncastuximab tesirine-lpyl |
| Â | Topoisomerase I inhibitors | DXd |
| Â | PBD | Zynlonta |
| Â | Duocarmycins | Trastuzumab duocarmazine |
RNA-targeting payload | Thailanstatin | MC-Thailanstatin A |
|  | Amatoxins | – |
Immune agonist | Toll-like receptor agonists | BDC-1001, Silverback |
| Â | STING agonists | XMT-2056 |
| Â | Glucocorticoid receptor modulators | ABBV-319 |