Fig. 6
From: Challenges and strategies associated with CAR-T cell therapy in blood malignancies
Optimization strategies for CAR-T cells. A: Multi-targeted CAR-T cells. B: Armored CAR-T cells. C: Universal CAR-T-Cells. D: Promoting the differentiation of CAR-T cells into central memory T cells (TCM) and stem cell memory T cells (TSCM). E: An appropriate co-stimulatory molecule. Three signaling domains of CD28, 4-1BB, and CD3zeta construct P28BBz receptor outperforms receptors containing only one or two of these domains. F: Humanized CAR-T cells