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Fig. 9 | Experimental Hematology & Oncology

Fig. 9

From: Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia

Fig. 9

Mechanistic scheme underlying the synergistic activity of DAC with erastin/RSL3. DAC increases MAGEA6 expression by reducing the frequency of methylation at the MAGEA6 promoter. Overexpression of MAGEA6 induces the degradation of AMPK protein and the inhibition of AMPK activation, leading to the decreased expression of SLC7A11 and attenuated GPX4 enzyme activity. Thus, DAC synergizes with erastin/RSL3 to augment ferroptosis in AML cells

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Experimental Hematology & Oncology

ISSN: 2162-3619

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