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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia

Fig. 5

Overexpression of SLC7A11 or GPX4 rescues DAC + RSL3-induced decrease in viability. (A) Western blot was performed in MOLM-13 and MV4-11 cells, which were overexpressed with SLC7A11 or NC. (B and C) Viability was measured in Ctrl- or DAC + RSL3-treated MOLM-13 and MV4-11 cells, which were further overexpressed with SLC7A11 or NC. (D) Western blot was performed in MOLM-13 and MV4-11 cells, which were overexpressed with GPX4 or NC. (E and F). Viability was measured in Ctrl or DAC + RSL3-treated MOLM-13 and MV4-11 cells overexpressing GPX4 or NC. ***P < 0.001

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Experimental Hematology & Oncology

ISSN: 2162-3619

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