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Fig. 7 | Experimental Hematology & Oncology

Fig. 7

From: Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins

Fig. 7

The LAMP5-AS1-DOT1L-LAMP5 axis suppresses autophagy and maintains MLL fusion protein. (a) The resulting decline in MLL-AF9 levels by knocking down either LAMP5-AS1 was reversed upon treatment with the autophagy inhibitor bafilomycin A1 (25 nM, 12 h). MLL-AF9, LC3B-II, and LAMP5 were assayed by western blotting, and beta-tubulin as a loading control. The MLL-AF9, LC3B-II, or LAMP5 /Tubulin densitometric ratio were recorded by ImageJ. (b) Proposed model for the LAMP5-AS1-DOT1L-LAMP5 axis regulates autophagy and maintains MLL fusion protein

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Experimental Hematology & Oncology

ISSN: 2162-3619

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