Table 1 The properties of dual-targeted CAR T cells :
Product | Targets | Costimulatory domain | CAR generation | Transduction | Source of T cells | Refs. |
|---|---|---|---|---|---|---|
CART19/20 | CD19/CD20 | 4-1BB | Second | Lentiviral | Autologous TN/MEM cells | [3] |
LV20.19 | CD19/CD20 | 4-1BB | Second | Lentiviral | Autologous T cells with TSCM and TCM phenotype | [4] |
C-CAR039 | CD19/CD20 | 4-1BB | Second | NA | Autologous T cells | [5] |
ATA3431 | CD19/CD20 | NA | NA | NA | Allogeneic T cells from healthy donor with TCM phenotype | [6] |
API-192 | CD19/CD20 | NA | Fourth, armored with IL-15 | NA | Human cord blood CD34 hematopoietic stem and progenitor cell-derived NKT cells | [7] |
UCART20 × 22 | CD20/CD22 | NA | NA | Lentiviral | Allogeneic T cells from healthy donor | [8] |
CD19/CD70 CAR T cells | CD19/CD70 | CD28/CD27 | Third | Lentiviral | Autologous T cells | [9] |
CD19/CD133 CAR T cells | CD19/CD133 | CD19: CD28 CD133: 4-1BB | Second | NA | Allogeneic iNKT cells from healthy donor | [10] |
GC012F | BCMA/CD19 | NA | NA | NA | Autologous T cells | [11] |
TIM3/CLEC12a CAR T cells | TIM3/CLEC12a | CD28/4-1BB | Third | Retroviral | Autologous T cells | [12] |