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Fig. 5 | Experimental Hematology & Oncology

Fig. 5

From: METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control

Fig. 5

METTL1 knockdown inhibits cellular nascent protein synthesis in THP-1 cells. A Western blotting confirmation of METTL1 knockdown using siRNAs in THP-1 cells. B The level of OPP means fluorescence intensity (MFI) in METTL1 knockdown (siMETTL1) and METTL1 control (siNC) THP-1 cells. Left panels: representative images. Right panels: quantification data. C Transcriptome sequencing analysis of gene changes in THP-1 cells upon METTL1 knockdown. D The top 20 down-regulation proteins in METTL1 knockdown THP1 cells compared to the controls. E GO enrichment analysis of down-regulation proteins in METTL1 knockdown THP-1 cells. Data were presented as mean ± SEM (Student’s t test, ***p < 0.001)

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Experimental Hematology & Oncology

ISSN: 2162-3619

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