Fig. 9

An overview schematic illustrating interactions between FAK inhibitor, tumor microenvironment and PD-1 blockade. Upon FAK inhibition, “immune-cold” KL tumors were converted into “immune-hot” tumors, with decreased collagen deposition and facilitated infiltration of anti-tumor immune cells, including CD8⁺ T cells, DC cells and M1-like macrophages into tumors, additionally, CXCL1 and CXCL2 were downregulated and CXCL9 was upregulated, thus responded favorably to PD-1 blockade