Fig. 1

The efficacy of immunotherapy in KL and KP tumors. A Survival data extracted from public database. PFS data was extracted from OAK and POPLAR and OS data was extracted from OAK, POPLAR and MSKCC. The log-rank test was used for comparison of survival outcomes with Kaplan–Meier method. p values are shown. B Diagram depicting treatment schedule for subcutaneous KP and KL tumor models. C, D Identification of LKB1 expression, tumor volume change and body weight of subcutaneously implanted KP or KL tumors in treatment of control or anti-PD1 group (n = 5–8 per group). Statistical analysis was performed using unpaired Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001, and ^nsp-values with no statistical difference. KL, KRAS^G12DLKB1^−/−; KP, KRAS^G12DTP53^−/−; PFS, progression-free survival; OS, overall-survival; LKB1, liver kinase B1; PD1, programmed death-1