Fig. 2

ctDNA and tumor DNA show variable concordance in the detection of molecular alterations. A, B Oncoplot of mutations detected in tumor (A) or liquid (B) biopsies in 32 patients with paired samples available. Left panel: white stars represent mutations that were found both in the tumor and in ctDNA. Right panels show somatic interactions of the top 20 altered genes in each sample type. C Venn Diagram showing the conservation of IDH1, ATM, FGFR2 and KRAS alterations between ctDNA and tissue biopsies; boxes below the Venn diagram depict the proportion of actionable mutations. D Scatter plot showing the correlation between the number of alterations in ctDNA and tissue DNA in all tumor samples (n = 30, after exclusion of the two outlier patients with MSI-H/MMRd tumors; Spearman correlation score r = 0.4148, p-val = 0.0227, two-tailed t-test). E Scatter plot showing the correlation between the number of alterations in ctDNA and tumor samples in patients with concomitant samplings only (n = 8; Spearman correlation score r = 0.9212, p-val = 0.0023, two-tailed t-test)