Fig. 5
From: The roles of tissue resident macrophages in health and cancer
Langerhans cells (LCs) exhibit anti-tumor effects. LCs induce proliferation of T cells and enhance the production of IFN-γ. The potency of LCs in T cell response is further enhanced through activation with TLR-3. PAK1 expressed on LCs regulates the number of epidermal stem cells, thereby exerting inhibitory effects on tumor proliferation. CD207 and a glycomimetic Langerin ligand liposomes 22 can serve as transcutaneous cancer vaccine agents via inducing protective T cell immunity