Fig. 1
From: The roles of tissue resident macrophages in health and cancer
The identity of TRMs is determined by their specific niche of residence. TRMs in different tissues originate from the embryo and rely on distinct niche signals and transcription factors to facilitate their differentiation, survival and self-maintenance. Additionally, TRMs in the lung, liver, brain, skin, and intestine secrete various cytokines and exhibit distinct markers. These factors collectively define the specific identity of TRMs