Fig. 1
Typical treatment journey of patients receiving CNS Prophylaxis at the National Cancer Centre Singapore. A Patients receiving outpatient chemotherapy with intrathecal methotrexate administered via lumbar puncture in ambulatory setting. B Patients receiving outpatient chemotherapy and later being admitted for inpatient intravenous methotrexate. Patients remain admitted for pre-treatment hyperhydration and alkalinization as well as post-treatment folinic acid rescue and drug clearance. *Note that there may be variation in practices across different institutions around the world