Table 2 Features and functions of gasdermin family
From: The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
Human gasdermin | Mouse gasdermin | Activated by | Tissue expression | Related cancers |
|---|---|---|---|---|
GSDMA | Gsdma1, Gsdma2, Gsdma3 | streptococcal pyrogenic exotoxin B | Skin, gastrointestinal tract | Gastric cancer, ovarian cancer |
GSDMB | N | GZMA, GZMB, caspase3/6/7 | Normal tissues and tumor cells | Gastric cancer, cervical cancer, hepatocarcinoma, bladder cancer, clear cell renal cell carcinoma, bladder cancer |
GSDMC | Gsdmc1, Gsdmc2, Gsdmc3, Gsdmc4 | Caspase8 | Melanoma cells | Melanoma, lung adenocarcinoma, breast cancer, gastric cancer, colorectal cancer, kidney clear cell cancer |
GSDMD | Gsdmd | Caspase1/4/5/8/11, neutrophil elastase, cathepsin G | Nucleus, plasma membrane | Hepatocellular carcinoma, non-small lung cancer, gastric cancer, |
GSDME | Gsdme | Caspase3 | Plasma membrane, mitochondrial | Breast cancer, lung adenocarcinoma, oesophageal squamous cell carcinoma, oral squamous cell carcinoma, colorectal cancer, |