Fig. 6
From: The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
Potential strategies for targeting pyroptosis in cancer treatment. A A bioorthogonal chemical system in which cancer-imaging Phe-BF3 selectively cleaves GSDMA3 to induce pyroptosis. B NK cells and CTL-derived GZMA cleave GSDMB to induce pyroptosis. C Intravenous delivery of live Listeria activates caspase-8 and cleaves GSDMC. Although almost all chemotherapy drugs can promote GSDMC expression and nPD-L1 translocation, only antibiotics, such as daunorubicin, doxorubicin, epirubicin, and actinomycin-D, have been demonstrated to activate caspase-8 and then cleave GSDMC to induce pytoptosis initiation in cancer cells. D Cisplatin, Cucurbitacin B, ZrNPs, and CXCR4-targeted nanotoxins induce cancer cell pyroptosis by activating the caspase-1/GSDMD pathway. E Chemotherapeutic drugs switch from apoptosis to pyroptosis by activating caspase-3 to cleave GSDME. Phe-BF3 Phenylalanine trifluoroborate, GSDMA Gasdermin A, NK Natural killer, CTLs cytotoxic T lymphocytes, GZMA Granzyme A, GSDMB Gasdermin B, GSDMC Gasdermin C, ZrNPs K3ZrF7: Yb/Er upconversion nanoparticles