Fig. 2
From: A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease
A RT-qPCR assessment of miR-148a-3p expression in the discovery cohort when comparing MPD and BPD. B A ROC curve was used to demonstrate the diagnostic power of miR-148a-3p in discriminating BPD from MPD including IPCM (AUC = 0.753) and excluding IPMC (AUC = 0.797). C Relative expression of miR-148a-3p in the validation cohort showed a significant difference in expression levels, when comparing BPD with MPD. D A ROC curve of miR-148a-3p in the validation cohort (AUC = 0.722), as well as when combining the validation cohort with the discovery cohort (AUC = 0.752). E Relative expression of miR-194-5p in PDAC vs. CCA in the combined cohort (P = 0.002). F Relative expression of miR-125b-5p in PDAC vs. CCA (P = 0.091) in the combined cohort. G Combining miR-125b-5p and miR-194-5p resulted in improved diagnostic power within the validation cohort (AUC = 0.815) and the combined cohort (AUC = 0.814).