Table 1 MM-associated immune checkpoints and their ligands, gene locations, and expressing cells
From: Immune checkpoint inhibitors for multiple myeloma immunotherapy
Immune checkpoint | Ligands | Genes location | Expression cells |
|---|---|---|---|
CTLA-4 | CD80/CD86 | 2q33.2 | T Cell |
PD-1 | PD-L1/PD-L2 | 2q37.3 | T Cell/NK cell |
LAG-3 | MHC II | 12p13.31 | T Cell/NK cell |
TIM-3 | Galectin-9/Ceacam-1/HMGB1 | 5q33.3 | T Cell/NK cell |
TIGIT | CD115/CD112 | 3q13.31 | T Cell/NK cell |
VISTA | VISIG-3 | 10q22.1 | T Cell |
BTLA | HVEM | 3q13.2 | T Cell |
KIR | HLA-C | 19q13.4 | T Cell/NK cell |