Table 1 CD22 ADC/recombinant immunotoxin structures
ADC/recombinant immunotoxin | Anti-CD22 antibody | Cytotoxic payload | Linker | Disease |
|---|---|---|---|---|
BL22 | RFB4 dsFv | Pseudomonas exotoxin A (PE38) | mc-VC-PABC (enzyme cleavable) | R/R HCL |
Moxetumomab pasudotox/HA22 | RFB4 dsFv (SSY-THW) | Pseudomonas exotoxin A (PE38) | mc-VC-PABC (enzyme cleavable) | R/R B-cell HCL |
Pinatuzumab vedotin | Hu10F4 antibody | Monomethyl auristatin E | mc-VC-PABC (enzyme cleavable) | R/R B-cell NHL |
Anti-CD22-NMS249 | Hu10F4 antibody | PNU-159682 | mc-VC-PABC (enzyme cleavable) | R/R B-cell NHL |
Anti-CD22-(LC:K149C)-SN36248 | Hu10F4 antibody | SN36248 × 2 | maleimide linker (uncleavable) | B-cell NHL |
Inotuzumab ozogamicin | G544 antibody | Calicheamicin (Calich-DMH) | hydrazone (acid-labile linker) | R/R B-ALL |