Table 2 Cancer-related circRNAs

Hematologic malignancies

AML

Circ_0009910

Up

Silencing Circ_0009910 can significantly inhibit proliferation, sphere formation and promote apoptosis

[226]

AML

Circ-SFMBT2

Up

Silencing Circ-SFMBT2 can inhibit the proliferation, migration, invasion and glycolysis of AML cells and induce apoptosis

[227]

AML

circ_0040823

Down

Overexpression of circ_0040823 inhibited the proliferation of AML cells and induced apoptosis and cell cycle arrest

[184]

AML

hsa_circ_0079480

Up

Associated with overall survival and relapse-free survival of AML

[228]

AML

circ_0004277

Down

Overexpression of circ 0004277 inhibited the migration and invasion of AML cells

[183]

ALL

Circ_0000745

Up

Knockdown of Circ_0000745 inhibits cell cycle progression and glycolysis, and induces apoptosis and iron death

[229]

ALL

circ_0008012

Up

related to proliferation and apoptosis of ALL cells

[230]

CLL

circ-CBFB

Up

Knockdown of circ-CBFB inhibited the proliferation of CLL cells, stopped the cell cycle and induced apoptosis

[231]

CLL

hsa_circ_0132266

Down

Inhibition of CLL cell apoptosis and impaired proliferation

[232]

CLL

Hsa_circ_0064574

Up

highly expressed in the plasma of CLL patients

[233]

CLL

circZNF91

Up

Silencing circZNF91 can inhibit CLL cell proliferation, induce apoptosis and block cell cycle

[234]

CML

Hsa_circ_0058493

Up

Increase the resistance of CML cells to imatinib

[235]

CML

circ_0080145

Up

Increase the resistance of CML cells to imatinib

[236]

CML

circ_0051886

Up

Increase the resistance of CML cells to imatinib

[236]

MM

Circ_0000190

Down

Inhibiting the viability, proliferation and inducing apoptosis

[237]

MM

hsa_circ_0007841

Up

Associated with drug resistance and chromosome aberration

[38]

MM

circITCH

Down

Related to the resistance of MM cells to bortezomib (BTZ)

[238]

Digestive system malignancy

CRC

Hsa_circ_0082182

Up

Associated with tumor proliferation and lymph node metastasis

[239]

CRC

Hsa_circ_0000370

Up

Associated with tumor proliferation and lymph node metastasis

[239]

CRC

hsa_circ_0004585

Up

Positively correlated with tumor size

[240]

CRC

hsa_circ_0000567

Down

Negatively correlated with tumor size, lymph node metastasis, remote metastasis, and TNM staging

[241]

CRC

hsa_circ_0004771

Up

Upregulated in tumor cell-derived plasma exosomes

[242]

HCC

circIPO11

Up

Drives self-renewal of liver cancer

[123]

HCC

hsa_circ_0000798

Up

High expression in liver cancer tissues was negatively correlated with the overall survival cycle of patients

[243]

HCC

hsa_circ_0027089

Up

Distinguishing cirrhosis

[244]

HCC

hsa_circ_0058124

Up

Associated with invasive characteristics, also regulates the resistance of liver cancer cells to sorafenib

[245]

HCC

hsa_circSMARCA5

Down

Related to proliferation, invasion and metastasis

[246]

HCC

hsa_circ_0068669

Down

Related to tumor microvascular invasion and TNM staging

[247]

HCC

hsa_circ_0028502

Down

associated with lymph node metastasis and TNM stage

[248]

HCC

hsa_circ_0076251

Down

Associated with Barcelona Clinic Liver Cancer (BCLC) stage

[248]

HCC

circUBAP2

Up

Negatively correlated with aggressive clinical characteristics

[249]

HCC

circRNA-YBX1

Down

Mediate phase separation suppresses the metastasis

GC

circNRIP1

Inhibit the growth of gastric cancer

[179]

GC

hsa_circ_0003159

Down

Negative correlation between tumor metastasis and TNM stage

[250]

GC

hsa_circ_0000096

Down

Affects the growth and migration of GC cells

[251]

GC

hsa_circ_002059

Down

Associated with distal metastasis of tumor cells and TNM staging

[252]

GC

hsa_circ_0000190

Down

Related to tumor diameter, lymphoid metastasis, distal metastasis and TNM stage

[253]

GC

hsa_circ_0000181

Down

Associated with tumor diameter, lymphoid metastasis

[254]

GC

hsa_circ_0000467

Up

Closely related to TNM staging

[255]

GC

hsa_circ_0001895

Down

Down-regulated in GC tissue and precancerous stage of GC

[256]

GC

hsa_circ_0017728

Up

Associated with short overall survival, poor pathological differentiation, higher TNM stage and lymph node metastasis

[257]

GC

circPDIA4

Up

Accelerate the invasion of cancer cells in vitro, promote the progression of GC and indicate poor prognosis

[258]

BC

Hsa_circ_0001136

Up

Associated with tumor grade, tumor stage, lymph node invasion and distal metastasis

[259]

BC

hsa_circ_0137439

Up

Related to tumor grade, tumor stage, lymph node invasion, also can distinguish between MIBC and NMIBC

[260]

BC

hsa_circ_0001361

Up

Promoted the invasion and metastasis of bladder cancer cells and was positively correlated with pathological grade

[261]

BC

circSLC8A1

Down

Overexpression inhibits the migration, invasion and proliferation of tumor cells

[262]

PC

circANAPC7

Down

Inhibits Tumor Growth and Muscle Wasting

[180]

PC

Circ-MBOAT2

Up

Regulates cell proliferation, migration, invasion and glutamine catabolism

[181]

PC

circRNA IARS

Up

Positively correlated with hepatic metastasis, vascular infiltration and TNM stage of pancreatic ductal adenocarcinoma (PDAC), and negatively correlated with postoperative survival time

[263]

PC

hsa_circRNA_001859

Down

Inhibit the proliferation, invasion and EMT of pancreatic cancer

[264]

OSCC

Hsa_circ_0001971

Up

Related to TNM stage of tumor

[265]

OSCC

Hsa_circ_0001874

Up

Related to tumor grade and TNM stage

[265]

OSCC

Hsa_circ_0003829

Down

Negatively correlated with lymph node metastasis and TNM stage

[266]

OSCC

Circ_0109291

Up

Silencing circ_0109291 can improve tumor sensitivity to DDP

[267]

ESCC

Hsa_circ_0003823

Up

Promotes the Tumor Progression, Metastasis and Apatinib Resistance

[167]

ESCC

circPUM1

Up

Regulates oxidative phosphorylation

[168]

ESCC

circCYP24A1

Up

Facilitates esophageal squamous cell carcinoma progression

[169]

ESCC

circCNOT6L

Up

Regulates cell development

[170]

ESCC

circGSK3β

Up

Promotes metastasis

[171]

EC

circ-VIM

Up

Silencing circ-VIM in vitro can inhibit immune escape and multiple carcinogenic activities of EC cells, as well as inhibit internal xenograft growth and lung metastasis

[182]

Lung cancer

LC

Hsa_circ_0001715

Up

Related to TNM stage and distant metastasis of lung adenocarcinoma, and inversely proportional to overall survival

[268]

LC

Hsa_circ_0005962

Up

Promote the proliferation of lung adenocarcinoma cells (LUAD)

[269]

LC

Hsa_circ_0086414

Down

Plasma hsa_circ_0086414 was related to EGFR mutations

[269]

LC

Hsa_circ_002178

Up

Promotes the expression of PDL1/PD1 in lung adenocarcinoma cells and is also present in exosomes

[270]

LC

Hsa_circ_0037515

Down

Significantly down-regulated in non-small cell lung cancer (NSCLC)

[271]

LC

Hsa_circ_0037516

Down

significantly down-regulated in non-small cell lung cancer

[271]

LC

hsa_circ_0001073

Down

Indicates the lung adenocarcinoma (LUAD) subtype in non-small cell lung cancer

[165]

LC

hsa_circ_0001495

Up

Indicates the squamous cell carcinoma (LUSC) subtype in non-small cell lung cancer

[165]

Others

RC

circHIAT1

Down

Overexpression inhibits the malignant progression of clear cell renal cell carcinoma

[272]

RC

hsa_circ_001895

Up

Promotes ccRCC cell proliferation, invasion and migration and is associated with poor prognosis

[273]

GM

circRNA-104718

Up

Indicates a poor prognosis and promotes invasion and migration of tumor cells

[274]

GM

circ-GLIS3

Up

Related to the resistance of temozolomide (TMZ) and promotes the proliferation, invasion and migration of glioma cells

[275]

GM

Circ_0047688

Up

Promote malignant behavior of glioma cells

[276]

GM

Circ_0001982

Up

Promote the proliferation, migration and invasion of glioma cells

[277]

GM

has-circ-0072688

Up

Promote the proliferation of glioblastoma and inhibit apoptosis

[278]

GM

hsa_circ_0030018

Up

Promote proliferation and inhibit apoptosis of glioma cells

[279]

Breast cancer

hsa_circ_0008673

Up

Related to tumor size and distal metastasis

[280]

Breast cancer

Circ-LARP4

Down

High expression indicates good prognosis and is negatively correlated with tumor size

[175]

Breast cancer

circRNA-CREIT

Down

Increases drug resistance in triple negative breast cancer (TNBC) and is associated with poor prognosis

[40]

OC

circBNC2

Down

associated with advanced cancer and lymph node metastasis in epithelial ovarian cancer (EOC)

[281]

TC

Hsa_circ_0137287

Down

related to tumor size, lymph node metastasis and TNM stage

[282]

CC

Circ_0000745

Up

Knockdown Circ_0000745 inhibited proliferation, migration, invasion and glycolysis of cervical cancer cells

[283]