Fig.6

CircRNA regulates therapy resistance. a circRNA-SORE acts as ceRNA to miR-103a-2-5p and miR-660-3p, and competitively activates Wnt2b translation to promote sorafenib resistance in HCC; it also binds to YBX1 and blocks PRP19-mediated YBX1 degradation to regulate sorafenib resistance. b circCDYL2 enhances the interaction between GRB7 and FAK, thereby activates AKT and ERK1/2 signaling pathways to promote trastuzumab resistance in breast cancer. Circ-HER2 can also encode a small protein HER2-103, which promotes homo/hetero dimerization of epidermal growth factor receptor (EGFR)/HER3, and actives AKT phosphorylation, which endows the sensitivity to Pertuzumab in triple-negative breast cancer. c circMYBL2 regulates FLT3-ITD translation by binding of PTBP1 to FLT3 messenger RNA in quizartinib-resistant FLT3-ITD AML. d circRNA-CREIT facilitates the interaction between PKR and the E3 ligase HACE1 and promoted proteasomal degradation of PKR protein, thereby attenuating the stress granules (SGs) assembly to activate the RACK1/MTK1 apoptosis signaling pathway and overcome doxorubicin resistance