Data source | OS curve | Proportion in OS (%) | Median OS, month | Mean OS, month | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
6 months | 1 year | 2 years | 3 years | 4 years | 5 years | 10 years | 15 years | 20 years | 25 years | ||||
Dependent 1-knot spline normal (base-case analysis) | NIVO | 89.9 | 75.0 | 53.0 | 38.5 | 29.0 | 22.4 | 8.3 | 3.9 | 2.2 | 1.3 | 26.0 | 45.5 |
EVE | 84.4 | 66.0 | 42.6 | 29.0 | 20.7 | 15.4 | 4.9 | 2.2 | 1.1 | 0.6 | 19.4 | 34.8 | |
Independent Weibull curves | NIVO | 90.0 | 76.5 | 53.9 | 36.6 | 24.1 | 15.6 | 1.4 | 0.1 | < 0.01 | < 0.001 | 26.3 | 34.0 |
EVE | 84.3 | 67.6 | 43.9 | 28.0 | 17.6 | 11.0 | 1.0 | 0.1 | < 0.01 | < 0.001 | 20.4 | 28.3 | |
Dependent log-logistic curve | NIVO | 89.7 | 74.8 | 53.0 | 39.0 | 29.9 | 23.8 | 10.6 | 6.3 | 4.3 | 2.9 | 26.0 | 50.9 |
EVE | 85.0 | 65.9 | 42.3 | 29.3 | 21.7 | 16.9 | 7.2 | 4.2 | 2.8 | 1.9 | 19.1 | 39.5 | |
CheckMate 025 | NIVO | 89.2 | 76.0 | – | – | – | – | – | – | – | – | 25.0 | – |
EVE | 81.2 | 66.7 | – | – | – | – | – | – | – | – | 19.55 | – | |
CA209-003 | NIVO | 82.4 | 70.6 | 48.1 | 41.2 | 37.8 | 34.3 | – | – | – | – | 22.4a | – |
EVE | – | – | – | – | – | – | – | – | – | – | – | – |